# E126: Risk Signals, JAKs, and SELECTIVE-ity

Page: https://stenobird.com/podcast/the-evidence-based-rheumatology-podcast-1130175/e126-risk-signals-jaks-and-selective-ity
Text version: https://stenobird.com/podcast/the-evidence-based-rheumatology-podcast-1130175/e126-risk-signals-jaks-and-selective-ity.md
Podcast: [The Evidence Based Rheumatology Podcast](https://stenobird.com/podcast/the-evidence-based-rheumatology-podcast-1130175)
Published: 2025-09-08T17:45:15+00:00
Episode link: https://msputman.podbean.com/e/e126-risk-signals-jaks-and-selective-ity/
Audio file: https://mcdn.podbean.com/mf/web/xgd7xbymdz4swrep/e126.mp3
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JSON: https://stenobird.com/v1/public/podcasts/the-evidence-based-rheumatology-podcast-1130175/episodes/e126-risk-signals-jaks-and-selective-ity
Duration seconds: 874

## Resource

Covering an interesting but ultimately disappointing post hoc study of multiple upadacitinib trials in RA. Initially some hope for clarity in the "Do JAKs cause all the badness?" questions, but ultimately landing me about where I have been since ORAL-SURVEILLANCE was published Paper: https://www.sciencedirect.com/science/article/pii/S0003496724423091

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## Transcript

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