# #1235 Nicole Rust: Why Neuroscience Hasn’t Solved Brain Disorders―and How We Can Change That

Page: https://stenobird.com/podcast/the-dissenter-1161217/1235-nicole-rust-why-neuroscience-hasn-t-solved-brain-disorders-and-how-we-can-change-that
Text version: https://stenobird.com/podcast/the-dissenter-1161217/1235-nicole-rust-why-neuroscience-hasn-t-solved-brain-disorders-and-how-we-can-change-that.md
Podcast: [The Dissenter](https://stenobird.com/podcast/the-dissenter-1161217)
Published: 2026-04-02T18:00:00+00:00
Episode link: https://podcasters.spotify.com/pod/show/thedissenter/episodes/1235-Nicole-Rust-Why-Neuroscience-Hasnt-Solved-Brain-Disordersand-How-We-Can-Change-That-e36t3rm
Audio file: https://anchor.fm/s/822ba20/podcast/play/106908982/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2025-7-15%2Feb8f9a73-62bd-3da4-65b1-5b2c7c60cb4d.m4a
Processing state: not_requested
JSON: https://stenobird.com/v1/public/podcasts/the-dissenter-1161217/episodes/1235-nicole-rust-why-neuroscience-hasn-t-solved-brain-disorders-and-how-we-can-change-that
Duration seconds: 3612

## Resource

******Support the channel****** Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuy PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on****** Website: https://www.thedissenter.net/ The Dissenter Goodreads list: https://shorturl.at/7BMoB Facebook: https://www.facebook.com/thedissenteryt/ Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Nicole Rust is Professor of Psychology at the University of Pennsylvania. What in the brain drives answers to the question, “Have you seen this before?” or “How happy are you right now?”. While different in many ways, memory and mood are both forms of learning that happen continuously throughout our lives. To understand how the brain supports these mysterious functions, her lab combines investigations of human behavior, measurements and manipulations of neural activity, and computational modeling. She is the author of Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders―and How We Can Change That. In this episode, we focus on Elusive Cures. We talk about different frameworks in neuroscience, including the molecular neuroscience framework, and complex systems theory. We discuss how brain drugs are developed. We walk through the history of the development of treatments for psychosis, depression, schizophrenia, and Alzheimer’s. We talk about how to find the causes of brain dysfunction, causality in the case of opioid dependence an…

## Actions

- request_transcript: `POST https://stenobird.com/v1/public/podcasts/the-dissenter-1161217/episodes/1235-nicole-rust-why-neuroscience-hasn-t-solved-brain-disorders-and-how-we-can-change-that/transcription-requests` — Idempotently request low-priority transcript generation for this episode.
- read_markdown: `GET https://stenobird.com/podcast/the-dissenter-1161217/1235-nicole-rust-why-neuroscience-hasn-t-solved-brain-disorders-and-how-we-can-change-that.md` — Read the agent-friendly Markdown representation of this episode resource.

A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed.

## Transcript

Full transcripts are not published on public pages unless there is a clear rights basis.