# Reprogramming T Cells to Cross the Brain’s Border

Page: https://stenobird.com/podcast/the-bio-report-1092382/reprogramming-t-cells-to-cross-the-brain-s-border
Text version: https://stenobird.com/podcast/the-bio-report-1092382/reprogramming-t-cells-to-cross-the-brain-s-border.md
Podcast: [The Bio Report](https://stenobird.com/podcast/the-bio-report-1092382)
Published: 2026-02-04T08:00:00+00:00
Episode link: https://thebioreport.podbean.com/e/reprogramming-t-cells-to-cross-the-brain-s-border/
Audio file: https://mcdn.podbean.com/mf/web/fvvwqijjvj657deu/BR-Michael_Roberts_-_2-4-26b4qpw.mp3
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JSON: https://stenobird.com/v1/public/podcasts/the-bio-report-1092382/episodes/reprogramming-t-cells-to-cross-the-brain-s-border
Duration seconds: 2327

## Resource

One of the challenges of treating brain tumors is delivering potent biologic therapies across the blood-brain barrier. Adaptin Bio has developed platform technology that harnesses a patient’s own T cells to transport bispecific therapeutic payloads across the blood-brain barrier and into other targeted tissue with an initial focus on treating glioblastoma. We spoke to Michael Roberts, co-founder and CEO of Adaptin Bio, about the unmet need in glioblastoma, the limitations of current blood-brain barrier–crossing strategies, and how the company’s platform seeks to change the treatment paradigm by using patient-derived T cells as delivery vehicles for targeted biologics.

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## Transcript

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