# Outsmarting Resistance with Rhythm

Page: https://stenobird.com/podcast/the-bio-report-1092382/outsmarting-resistance-with-rhythm
Text version: https://stenobird.com/podcast/the-bio-report-1092382/outsmarting-resistance-with-rhythm.md
Podcast: [The Bio Report](https://stenobird.com/podcast/the-bio-report-1092382)
Published: 2026-03-18T07:00:00+00:00
Episode link: https://thebioreport.podbean.com/e/outsmarting-resistance-with-rhythm/
Audio file: https://mcdn.podbean.com/mf/web/d7zvbyc23rfaxs3t/BR-Ben_Zeskind-3-18-269jmic.mp3
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JSON: https://stenobird.com/v1/public/podcasts/the-bio-report-1092382/episodes/outsmarting-resistance-with-rhythm
Duration seconds: 2299

## Resource

Pancreatic cancer remains one of oncology’s deadliest diagnoses, with standard treatments often offering only transient tumor shrinkage at the cost of grueling side effects and rapid resistance. Immuneering is using transcriptomic and informatics tools to design a MEK inhibitor dosed in intense daily pulses rather than continuously. This approach aims to restore a more normal signaling rhythm in healthy cells while repeatedly ambushing tumors. Ben Zeskind, CEO of Immuneering, discusses how the company is using its informatics-driven dosing regimen to re-engineer targeted cancer therapy so it extends survival, delays resistance, and is better tolerated.

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## Transcript

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