# GLP-1s and Muscle Loss: What Ozempic Users Need to Know

Page: https://stenobird.com/podcast/stronger-weekly-6715416/glp-1s-and-muscle-loss-what-ozempic-users-need-to-know
Text version: https://stenobird.com/podcast/stronger-weekly-6715416/glp-1s-and-muscle-loss-what-ozempic-users-need-to-know.md
Podcast: [Stronger Weekly](https://stenobird.com/podcast/stronger-weekly-6715416)
Published: 2026-05-20T11:15:00+00:00
Episode link: https://podcasters.spotify.com/pod/show/strongerweekly/episodes/GLP-1s-and-Muscle-Loss-What-Ozempic-Users-Need-to-Know-e3jk0gj
Audio file: https://anchor.fm/s/edf4bad0/podcast/play/120242131/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-4-19%2F424490217-44100-2-d4d97d49bb965.mp3
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JSON: https://stenobird.com/v1/public/podcasts/stronger-weekly-6715416/episodes/glp-1s-and-muscle-loss-what-ozempic-users-need-to-know
Duration seconds: 2381

## Resource

One in eight American adults have now tried a GLP-1 (Ozempic, Wegovy, Mounjaro, Zepbound). The drugs work—people lose 15-22% of their body weight in clinical trials. But new research published this month confirms what many suspected: 25-40% of that weight loss is muscle, not fat. That is catastrophic for long-term metabolic health, strength, and healthspan. This episode breaks down the latest meta-analysis, explains why muscle loss matters (it's not just vanity—muscle is your metabolic engine, structural support, and predictor of longevity), and offers five practical steps to preserve muscle if you're on or considering GLP-1s. If you're considering GLP-1s, on them currently, or have an aging parent using them—this is the conversation you need to hear. PLUS THIS WEEK'S HEALTH & FITNESS NEWS - Mayo Clinic’s AI detects pancreatic cancer up to 3 years before clinical diagnosis - Tick bite surge — early-season Lyme disease risk hits the Northeast - The simple at-home strength test JAMA Network Open just linked to longevity - The exact daily step count that prevents weight regain after dieting - GLP-1 muscle loss — the biggest health and fitness story of the week SPONSORS/PRODUCTS I USE - Get nutritional supplements that work as hard as you do: ⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.puristnutrition.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Upgrade to natural, high-quality male-grooming products at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.basedbodyworks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ , and use code word STRONGERWEEKLY for 20% off - Build a world-class home gym with Rep Fitness: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.repfitness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - Bulletproof your drinking with Clutch; medication-assisted treatment from Oar Health: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/OarStrength⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠…

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