# 154: Physiology-Guided Sepsis Resuscitation: ANDROMEDA-SHOCK 2, Dynamic Fluid Responsiveness, and SEP-1 with Guest Jaclyn Bond

Page: https://stenobird.com/podcast/rapid-response-rn-1369016/154-physiology-guided-sepsis-resuscitation-andromeda-shock-2-dynamic-fluid-responsiveness-and-sep-1-with-guest-jaclyn-bond
Text version: https://stenobird.com/podcast/rapid-response-rn-1369016/154-physiology-guided-sepsis-resuscitation-andromeda-shock-2-dynamic-fluid-responsiveness-and-sep-1-with-guest-jaclyn-bond.md
Podcast: [Rapid Response RN](https://stenobird.com/podcast/rapid-response-rn-1369016)
Published: 2026-01-16T11:00:00+00:00
Episode link: https://healthpodcastnetwork.com/show/rapid-response-rn/
Audio file: https://pscrb.fm/rss/p/episodes.captivate.fm/episode/12285ff7-8b2a-472f-9578-8c90a9c69825.mp3
Processing state: processed
JSON: https://stenobird.com/v1/public/podcasts/rapid-response-rn-1369016/episodes/154-physiology-guided-sepsis-resuscitation-andromeda-shock-2-dynamic-fluid-responsiveness-and-sep-1-with-guest-jaclyn-bond
Duration seconds: 2876

## Resource

The science is finally catching up to what clinicians have long known: more fluids aren't always the answer to septic shock. In this episode, host Sarah Lorenzini and Jaclyn Bond MSN-LM, MBA-HM explain what the ANDROMEDA-SHOCK 2 trial reveals about physiology-guided sepsis resuscitation and why fixed-volume fluid strategies can lead to avoidable harm. They break down how dynamic fluid responsiveness testing helps teams stop guessing, and how tools like FloPatch support real-time assessment of carotid flow time and stroke volume. You'll leave with a clearer idea of when to give fluids, when to stop, and how to justify the decision. Topics discussed in this episode: The purpose and key findings of the ANDROMEDA-SHOCK 2 study Why dynamic measures of fluid responsiveness matter more than static vitals What recent meta-analysis data shows about physiology-guided fluid strategies Carotid flow time: what it is, how it’s measured, and how it guides decisions Hemodynamic assessment and bedside limitations How FloPatch supports real-time assessment so you can make individualized fluid decisions SEP-1 2026 guideline updates and why it’s better for patients How to apply these principles to your workflow Website: www.flosonicsmedical.com See FloPatch in action: https://hubs.ly/Q03-68Hg0 Mentioned in this episode: Rapid Response Academy Winter 2026 Cohort https://www.rapidresponseandrescue.com/rra

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