# APOE4 Positive and Alzheimer's Risk: One Woman's 5-Year Brain Health Protocol

Page: https://stenobird.com/podcast/race-against-mind-an-alzheimer-s-prevention-investigation-7840812/apoe4-positive-and-alzheimer-s-risk-one-woman-s-5-year-brain-health-protocol
Text version: https://stenobird.com/podcast/race-against-mind-an-alzheimer-s-prevention-investigation-7840812/apoe4-positive-and-alzheimer-s-risk-one-woman-s-5-year-brain-health-protocol.md
Podcast: [Race Against Mind: An Alzheimer's Prevention Investigation](https://stenobird.com/podcast/race-against-mind-an-alzheimer-s-prevention-investigation-7840812)
Published: 2026-04-25T19:40:51+00:00
Episode link: https://api.riverside.com/hosting-analytics/media/9ef2588b4b1a1fcb5ca37219f00fd95484f6bff43d55046fb843b0c8d2915404/eyJlcGlzb2RlSWQiOiI2N2EyZDkyOC05YjFhLTRmYzItOWJjNi1jZWM4NDJkOWU2ZTMiLCJwb2RjYXN0SWQiOiIzYzlkNzlhZi01NGJjLTQ5OTEtODk3OC0zMDFmNzY3ODIyNjMiLCJhY2NvdW50SWQiOiI2OWNlYzc2YmQ2N2JlODBlMzA1OTE5MjAiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjllZDE4ZTYwZmJhNzA2M2E0OWZhMDZjL3NhcmFoLWt1aG5zLXN0dWRpby1Hd0NRMC1jb21wb3Nlci0yMDI2LTQtMjVfXzIxLTQxLTI2Lm1wMyJ9.mp3
Audio file: https://api.riverside.com/hosting-analytics/media/9ef2588b4b1a1fcb5ca37219f00fd95484f6bff43d55046fb843b0c8d2915404/eyJlcGlzb2RlSWQiOiI2N2EyZDkyOC05YjFhLTRmYzItOWJjNi1jZWM4NDJkOWU2ZTMiLCJwb2RjYXN0SWQiOiIzYzlkNzlhZi01NGJjLTQ5OTEtODk3OC0zMDFmNzY3ODIyNjMiLCJhY2NvdW50SWQiOiI2OWNlYzc2YmQ2N2JlODBlMzA1OTE5MjAiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjllZDE4ZTYwZmJhNzA2M2E0OWZhMDZjL3NhcmFoLWt1aG5zLXN0dWRpby1Hd0NRMC1jb21wb3Nlci0yMDI2LTQtMjVfXzIxLTQxLTI2Lm1wMyJ9.mp3
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Duration seconds: 1280

## Resource

Sarah is homozygous APOE4, the highest genetic risk profile for Alzheimer's disease. Her grandmother had it. Her mother was diagnosed at 58. When she got her own results, she didn't wait. In this first episode, she traces how a family legacy of Alzheimer's became a five-year personal research project and why the window for meaningful intervention is decades earlier than most people think. She breaks down what carrying two copies of APOE4 actually means, where the science is solid and where it falls short, and how she built a protocol around the pillars most likely to move the needle: nutrition, sleep, fitness, alcohol, and hormones. This is where it all starts. Show Notes & References

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## Transcript

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