# Modafinil (Provigil)

Page: https://stenobird.com/podcast/psychrounds-the-psychiatry-podcast-6714703/modafinil-provigil
Text version: https://stenobird.com/podcast/psychrounds-the-psychiatry-podcast-6714703/modafinil-provigil.md
Podcast: [PsychRounds: The Psychiatry Podcast](https://stenobird.com/podcast/psychrounds-the-psychiatry-podcast-6714703)
Published: 2026-06-03T04:09:00+00:00
Episode link: https://podcasters.spotify.com/pod/show/psychrounds/episodes/Modafinil-Provigil-e3k8qn1
Audio file: https://anchor.fm/s/eb936048/podcast/play/120924321/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-5-3%2F072fecfc-d06a-de5f-4dd3-170806c317c8.mp3
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JSON: https://stenobird.com/v1/public/podcasts/psychrounds-the-psychiatry-podcast-6714703/episodes/modafinil-provigil
Duration seconds: 1176

## Resource

Welcome back! Today, we are looking at Modafinil and it's nuanced use in psychiatry. References: Provigil (modafinil) [prescribing information]. North Wales, PA: Teva Pharmaceuticals USA, Inc. U.S. Food and Drug Administration. Available at: https://www.accessdata.fda.gov/drugsatfda docs/label/2015/020717s037s038lbl.pdf Schwartz JR. Modafinil in the treatment of excessive sleepiness. Drug Des Devel Ther. 2009;2:71–85. Kaplan S, Goehring EL Jr, Engel T, et al. Cardiovascular outcomes associated with modafinil in patients with obstructive sleep apnea. Pharmacoepidemiol Drug Saf. 2018;27(11):1182–1190. doi:10.1002/pds.4642 Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727–738. doi:10.1016/S2215-0366(18)30269-4 Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH. Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2013;74(11):1101–1107. doi:10.4088/JCP.13r08560 Bahji A, Mesbah-Oskui L. Comparative efficacy and safety of stimulant-type medications for depression: a systematic review and network meta-analysis. J Affect Disord. 2021;292:416–423. doi:10.1016/j.jad.2021.05.119 Nunez NA, Singh B, Jorgensen A, et al. Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: a meta-analysis of randomized controlled trials. Bipolar Disord. 2020;22(2):109–120. doi:10.1111/bdi.12859

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