# Episode 188: digital therapy, DKA with SGLT2s, esketamine for resistant depression, and what is a normal TSH

Page: https://stenobird.com/podcast/primary-care-update-1000928/episode-188-digital-therapy-dka-with-sglt2s-esketamine-for-resistant-depression-and-what-is-a-normal-tsh
Text version: https://stenobird.com/podcast/primary-care-update-1000928/episode-188-digital-therapy-dka-with-sglt2s-esketamine-for-resistant-depression-and-what-is-a-normal-tsh.md
Podcast: [Primary Care Update](https://stenobird.com/podcast/primary-care-update-1000928)
Published: 2025-08-29T00:52:05+00:00
Episode link: https://podcasters.spotify.com/pod/show/primary-care-update/episodes/Episode-188-digital-therapy--DKA-with-SGLT2s--esketamine-for-resistant-depression--and-what-is-a-normal-TSH-e37f8ib
Audio file: https://anchor.fm/s/5693a5c/podcast/play/107503627/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2025-7-29%2Fd15f1f89-2aec-83da-5626-2ed8545ef18c.mp3
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JSON: https://stenobird.com/v1/public/podcasts/primary-care-update-1000928/episodes/episode-188-digital-therapy-dka-with-sglt2s-esketamine-for-resistant-depression-and-what-is-a-normal-tsh
Duration seconds: 1978

## Resource

Join Kate, Mark, Gary and Henry as they discuss 4 great new POEMs (studies with the potential to change practice): a digital mental health intervention, the risk of DKA in patients using SGLT2 inhibitors, esketamine’s effects on suicidal ideation and unresponsive depression, and whether “one-size-fits-all” thyroid reference ranges misleading. Links: Essential Evidence Plus: www.essentialevidenceplus.com Digital mental health app for depression: https://pubmed.ncbi.nlm.nih.gov/40227715/ RIsk of DKA with SGLT2s: pubmed.ncbi.nlm.nih.gov/40070044/ Esketamine and resistant depression or suicidality: pubmed.ncbi.nlm.nih.gov/39790081/ What is a normal TSH: https://pubmed.ncbi.nlm.nih.gov/40324200/ Joseph O'Connor and the Escape Line Trilogy (2 great novels): https://www.amazon.com/The-Rome-Escape-Line-Trilogy-2-book-series/dp/B0BSNX3C89

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## Transcript

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