# HER2-Positive Metastatic Breast Cancer — An Interview with Prof Dr Sibylle Loibl on First-Line and Maintenance Therapy

Page: https://stenobird.com/podcast/oncology-today-with-dr-neil-love-1004241/her2-positive-metastatic-breast-cancer-an-interview-with-prof-dr-sibylle-loibl-on-first-line-and-maintenance-therapy
Text version: https://stenobird.com/podcast/oncology-today-with-dr-neil-love-1004241/her2-positive-metastatic-breast-cancer-an-interview-with-prof-dr-sibylle-loibl-on-first-line-and-maintenance-therapy.md
Podcast: [Oncology Today with Dr Neil Love](https://stenobird.com/podcast/oncology-today-with-dr-neil-love-1004241)
Published: 2026-07-17T13:00:00+00:00
Episode link: https://oncologytoday.captivate.fm/episode/6091-oncologytodayfirstlineher2posmbc26
Audio file: https://dts.podtrac.com/redirect.mp3/episodes.captivate.fm/episode/3fcfc54e-efea-4da8-8757-29dc956d19f9.mp3
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JSON: https://stenobird.com/v1/public/podcasts/oncology-today-with-dr-neil-love-1004241/episodes/her2-positive-metastatic-breast-cancer-an-interview-with-prof-dr-sibylle-loibl-on-first-line-and-maintenance-therapy
Duration seconds: 2788

## Resource

Featuring an interview with Prof Dr Sibylle Loibl, including the following topics: Perspectives on overall survival gains achieved over the years for patients with metastatic breast cancer (mBC) (0:00) Previous treatment and patient outcomes in the DESTINY-Breast09 trial of trastuzumab deruxtecan (T-DXd) with or without pertuzumab (5:35) Role of endocrine therapy in the treatment of hormone receptor-positive, HER2-positive mBC (8:01) Targeting the PI3K signaling pathway in HER2-positive mBC (11:08) Contraindications for T-DXd; T-DXd-associated gastrointestinal toxicities and interstitial lung disease (13:53) Optimal duration of and therapeutic partner for T-DXd as first-line maintenance therapy for patients with HER2-positive mBC (20:44) Case: A woman in her early 40s with metastatic relapse of HER2-positive breast cancer 2 years after completing neoadjuvant and adjuvant therapy (26:54) Role of exercise and weight control in the management of breast cancer; effect of pregnancy on the breast tumor immune environment (40:03) CME information and select publications

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