# 353. Spermidine Shows Promise for Boosting Vaccine Response - Life Extension

Page: https://stenobird.com/podcast/live-foreverish-71917/353-spermidine-shows-promise-for-boosting-vaccine-response-life-extension
Text version: https://stenobird.com/podcast/live-foreverish-71917/353-spermidine-shows-promise-for-boosting-vaccine-response-life-extension.md
Podcast: [Live Foreverish](https://stenobird.com/podcast/live-foreverish-71917)
Published: 2026-07-08T17:01:31+00:00
Episode link: https://liveforeverish.podbean.com/e/353-spermidine-shows-promise-for-boosting-vaccine-response-life-extension/
Audio file: https://mcdn.podbean.com/mf/web/nenkfx5ash7nm9k8/Podcast-July-2026-In-Out.mp3
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JSON: https://stenobird.com/v1/public/podcasts/live-foreverish-71917/episodes/353-spermidine-shows-promise-for-boosting-vaccine-response-life-extension
Duration seconds: 1672

## Resource

Spermidine Shows Promise for Boosting Vaccine Response A 2026 Aging Cell pilot study found that daily supplementation with 6 mg of spermidine was safe and well tolerated in adults over 65 years old following a SARS-CoV-2 vaccine booster. While overall immune responses were not significantly changed, older adults who had previously shown little or no vaccine response experienced notable improvements in anti-spike antibodies, neutralizing activity against multiple variants, and memory B-cell responses. The findings suggest that spermidine may help enhance immune resilience in vaccine non-responders by supporting cellular health and autophagy, a key process that declines with age. #LELearn #EDULiveforeverish

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## Transcript

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