# Kicking Alzheimer's Butt & Your Questions with Dr. Richard Isaacson

Page: https://stenobird.com/podcast/laugh-lines-with-kim-penn-holderness-743468/kicking-alzheimer-s-butt-your-questions-with-dr-richard-isaacson
Text version: https://stenobird.com/podcast/laugh-lines-with-kim-penn-holderness-743468/kicking-alzheimer-s-butt-your-questions-with-dr-richard-isaacson.md
Podcast: [Laugh Lines with Kim & Penn Holderness](https://stenobird.com/podcast/laugh-lines-with-kim-penn-holderness-743468)
Published: 2026-05-05T07:00:00+00:00
Episode link: https://shows.acast.com/holdermess-the-holderness-family-podcast/episodes/kicking-alzheimers-butt-your-questions-with-dr-richard-isaac
Audio file: https://sphinx.acast.com/p/open/s/618c3caaa322d1001350082c/e/69f25dabc5dd1a1717fdbc2b/media.mp3
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JSON: https://stenobird.com/v1/public/podcasts/laugh-lines-with-kim-penn-holderness-743468/episodes/kicking-alzheimer-s-butt-your-questions-with-dr-richard-isaacson
Duration seconds: 3442

## Resource

If you’ve been following along, you know Penn recently found out he has two copies of the APOE4 gene - basically the “high risk” genetic lottery for Alzheimer’s. And while we thought we were prepared for that news… we weren’t. It hit hard. For both of us. But this episode is not about fear. It’s about hope. This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn’s prevention plan and one of the leading voices in Alzheimer’s prevention) to answer YOUR questions. And wow, did you have questions. We discuss what to actually ask your doctor, what Penn is doing right now, prevention strategies that are showing promise, and how close we are to affordable, at-home Alzheimer’s risk testing. Spoiler: closer than you’d expect. But the biggest thing we discuss? Why genes are not your destiny. We also get very real about the emotional side of this, like what it’s like to love someone who might face this disease, what caregiving actually looks like, and why doing something now matters so much. If you or someone you love has concerns about Alzheimer's, this show is for you. Because for the first time, this doesn’t feel like a ticking time bomb. It feels like something we can actually fight. We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube . Learn more about Alzlabs testing Get free prevention support with Retain Your Brain Learn more about Dr. Richard Isaacson Visit Our Shop Join Our Newsletter Find us on Substack Follow us on Instagram Follow us on TikTok Follow us on Facebook Laugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content…

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