# Ep 386 - Sleep, Hypertrophy, and Creatine

Page: https://stenobird.com/podcast/iron-culture-presented-by-mass-6617631/ep-386-sleep-hypertrophy-and-creatine
Text version: https://stenobird.com/podcast/iron-culture-presented-by-mass-6617631/ep-386-sleep-hypertrophy-and-creatine.md
Podcast: [Iron Culture presented by MASS](https://stenobird.com/podcast/iron-culture-presented-by-mass-6617631)
Published: 2026-08-20T14:57:55+00:00
Episode link: https://podcasters.spotify.com/pod/show/massresearchreview/episodes/Ep-386---Sleep--Hypertrophy--and-Creatine-e3nllh3
Audio file: https://anchor.fm/s/e68ec484/podcast/play/124490723/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-7-20%2F8a3d7f20-2647-036e-157c-a030574d96b0.mp3
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JSON: https://stenobird.com/v1/public/podcasts/iron-culture-presented-by-mass-6617631/episodes/ep-386-sleep-hypertrophy-and-creatine
Duration seconds: 4751

## Resource

Trexler and Helms dig into sleep and how it intersects with body composition and supplementation. They open on the sleep-and-lifting landscape, then work through the frequently cited 2010 study on insufficient sleep and fat loss, laying out its design and the details behind its dramatic-sounding numbers. From there they discuss what the broader literature does and doesn't establish, the acute effects of sleep restriction on power, skill, and pain perception, and observational data — including sleep patterns in hunter-gatherer societies and among elite athletes — plus the relationship between sleep duration and sleep efficiency. The back half turns to supplementation. They trace the history of research on creatine and sleep, from early findings that creatine might reduce sleep need to newer work on brain creatine under sleep deprivation. This leads into a crossover trial testing caffeine and creatine against a sleep-deprivation cognitive challenge, its findings on rugby passing accuracy, and how to interpret an isolated positive result on a little-studied question. They cover a more recent high-dose replication, then close with the practical side — creatine dosing, the common report that creatine disrupts sleep, and caffeine timing — before wrapping up. Join us for a live recording of Iron Culture! We go live Tuesdays at 5:30 pm eastern time. Be sure to use code "MRR10" for 10% off your order at elitefts.com Iron Culture is proudly presented by the MASS Research Review massresearchreview.com Chapters 0:00 Intro 9:44 Sleep & body composition 11:16 Unpacking the famous 2010 sleep study 20:52 The blind spot in the sleep literature 23:04 Sleep restriction, power, skill & pain 27:20 Sleep duration vs. sleep efficiency 31:45 The big takeaway on sleep & g…

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## Transcript

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