# 058 Does mTOR determine your optimal training frequency?

Page: https://stenobird.com/podcast/hypertrophy-past-and-present-7348739/058-does-mtor-determine-your-optimal-training-frequency
Text version: https://stenobird.com/podcast/hypertrophy-past-and-present-7348739/058-does-mtor-determine-your-optimal-training-frequency.md
Podcast: [Hypertrophy Past and Present](https://stenobird.com/podcast/hypertrophy-past-and-present-7348739)
Published: 2026-06-29T04:05:08+00:00
Episode link: https://share.transistor.fm/s/234ed8a5
Audio file: https://media.transistor.fm/234ed8a5/b86672a0.mp3
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JSON: https://stenobird.com/v1/public/podcasts/hypertrophy-past-and-present-7348739/episodes/058-does-mtor-determine-your-optimal-training-frequency
Duration seconds: 5433

## Resource

In this episode of Hypertrophy Past & Present, Jake and Chris begin with a classic Clancy Ross full-body routine from the Silver Era, then move into a discussion about training frequency, mTOR, muscle protein synthesis, and whether training again before the previous hypertrophy stimulus has “finished” is actually a problem. Key topics include: • Clancy Ross’ 1940s full-body single set routine • Whether training a muscle every 48 hours can blunt hypertrophy • How repeated bout effect studies can be misapplied to training frequency • Why mTOR signalling is not the same thing as muscle growth • The role of oxidative stress and inflammation in post-workout recovery • How volume, frequency, stress, dieting, and athletic workloads affect recovery • Why the best training frequency is limited by recovery

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## Transcript

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