# Liver Lineup: Innovations in Cholestatic Disease Management, With Kris Kowdley, MD

Page: https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-innovations-in-cholestatic-disease-management-with-kris-kowdley-md
Text version: https://stenobird.com/podcast/hcplive-podcasts-19526/liver-lineup-innovations-in-cholestatic-disease-management-with-kris-kowdley-md.md
Podcast: [HCPLive Podcasts](https://stenobird.com/podcast/hcplive-podcasts-19526)
Published: 2026-02-03T21:47:21+00:00
Episode link: https://audioboom.com/posts/8856585
Audio file: https://audioboom.com/posts/8856585.mp3?modified=1770155320&sid=5004077&source=rss
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JSON: https://stenobird.com/v1/public/podcasts/hcplive-podcasts-19526/episodes/liver-lineup-innovations-in-cholestatic-disease-management-with-kris-kowdley-md
Duration seconds: 2165

## Resource

In this episode of Liver Lineup: Updates & Unfiltered Insights , host Nancy Reau, MD, sits down with Kris Kowdley, MD, to discuss evolving approaches in cholestatic liver disease, with a particular focus on primary biliary cholangitis (PBC). Key episode timestamps: 0:00:00 – Guest intro & evolution of PBC therapy 0:07:34 – Redefining biochemical response & earlier assessment 0:16:26 – OCA withdrawal & positioning PPARs/fibrates 0:22:16 – Diagnosing AMA‑negative PBC 0:25:58 – Genetic cholestasis panels & PFIC spectrum 0:29:45 – Symptom burden, pruritus, & IBAT inhibitors 0:35:17 – Bone health & closing remarks

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## Transcript

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