# Li Li: Rewiring Skin Aging With AI and mRNA

Page: https://stenobird.com/podcast/galaxy-balance-7619530/li-li-rewiring-skin-aging-with-ai-and-mrna
Text version: https://stenobird.com/podcast/galaxy-balance-7619530/li-li-rewiring-skin-aging-with-ai-and-mrna.md
Podcast: [Galaxy Balance](https://stenobird.com/podcast/galaxy-balance-7619530)
Published: 2026-07-27T21:37:39+00:00
Episode link: https://api.riverside.com/hosting-analytics/media/8a4222f882d014e077b062b691cbe04adb6cea6e339a1afca26aca74f8aec0b8/eyJlcGlzb2RlSWQiOiJiYTM3MDhjYS0wMmE0LTQ0YjYtYWU1Ni02ZDY3N2YyNjM0ZDkiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNmE2MDE2NDI0ZTI4MTQxYzRkYjk5ZDc0L2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTctMjJfXzMtMC01MC5tcDMifQ==.mp3
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JSON: https://stenobird.com/v1/public/podcasts/galaxy-balance-7619530/episodes/li-li-rewiring-skin-aging-with-ai-and-mrna
Duration seconds: 3454

## Resource

00:00 - Introduction to Lily and GLife’s vision for data-driven dermatology 01:20 - Lily’s scientific background 02:43 - Breakthroughs from single-cell atlases 03:50 - The motivation behind founding GLife 04:50 - The importance of treating skin as a foundational organ 05:48 - Discovery of key molecular drivers of aging 06:22 - Challenges of fundraising 07:45 - The novel approach to rejuvenating hair loss through targeted messenger RNA treatments 08:53 - How treatments will be delivered via microneedles and micro patches 09:32 - The potential to alter hair color and explore cosmetic applications 10:06 - Balancing platform discovery engines with the development of first-in-class therapeutics 10:43 - The comprehensiveness of the skin atlas and addressing genetic diversity 11:39 - Technical challenges of capturing skin’s cellular heterogeneity and stem cell populations 12:50 - The importance of isoforms and deep sequencing in understanding gene functions 13:16 - Short-lived messenger RNA as a safe, reversible treatment modality 14:55 - Safety considerations and toxicity management 16:01 - Biodistribution studies and local micro-needle delivery safety 17:00 - Next steps towards clinical trials and regenerative therapies for hair loss 18:08 - The role of big data and omics in understanding skin disorders and aging 19:04 - The significance of isoforms in skin biology and gene function 20:13 - Endogenous vs. modified messenger design for safety and efficacy 21:32 - Potential for multi-gene delivery to enhance hair regrowth and color restoration 22:22 - Conception of patches that work with existing hair without shaving 23:38 - Targeting broad hair loss types and the concept of root causes 24:47 - Modeling hair loss with animal models and regulatory considerations 25:48 - Regula…

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