# Christian Kramme: Rebuilding IVF with iPSC-Derived Support Cells

Page: https://stenobird.com/podcast/galaxy-balance-7619530/christian-kramme-rebuilding-ivf-with-ipsc-derived-support-cells
Text version: https://stenobird.com/podcast/galaxy-balance-7619530/christian-kramme-rebuilding-ivf-with-ipsc-derived-support-cells.md
Podcast: [Galaxy Balance](https://stenobird.com/podcast/galaxy-balance-7619530)
Published: 2026-02-23T23:50:01+00:00
Episode link: https://api.riverside.com/hosting-analytics/media/ee7b511a6acbae7dd3c80b04f64e8a5f5faf29bb9054d080111f66c87f7e394f/eyJlcGlzb2RlSWQiOiIzNjJlMGY0OC1jYTJkLTQzMDktYjU4OC0wOWE0ZGU2ODQyZWQiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjk5Y2UwYjhiYzkyZDY1MDFlZjUxYmZiL2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTItMjRfXzAtMjAtMjQubXAzIn0=.mp3
Audio file: https://api.riverside.com/hosting-analytics/media/ee7b511a6acbae7dd3c80b04f64e8a5f5faf29bb9054d080111f66c87f7e394f/eyJlcGlzb2RlSWQiOiIzNjJlMGY0OC1jYTJkLTQzMDktYjU4OC0wOWE0ZGU2ODQyZWQiLCJwb2RjYXN0SWQiOiJjMGE0YjQ3Yi1iMmM5LTRjNjgtODhiNS0xYmFhM2EzNTJjODMiLCJhY2NvdW50SWQiOiI2OTBiYjRiMzM2NjY3MWFlZGQwZTZhMTEiLCJwYXRoIjoibWVkaWEvY2xpcHMvNjk5Y2UwYjhiYzkyZDY1MDFlZjUxYmZiL2Nvcnktc21pdGhzLXN0dWRpby1sTktuWC1jb21wb3Nlci0yMDI2LTItMjRfXzAtMjAtMjQubXAzIn0=.mp3
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JSON: https://stenobird.com/v1/public/podcasts/galaxy-balance-7619530/episodes/christian-kramme-rebuilding-ivf-with-ipsc-derived-support-cells
Duration seconds: 3955

## Resource

In this episode of Galaxy Balance, Cory Smith is joined by Christian Kramme, Chief Scientific Officer of Gameto, a biotechnology company rethinking reproductive medicine through cell engineering, Christian's work focuses on using iPSC-derived ovarian support cells to improve IVF outcomes by enabling egg maturation outside the body, while avoiding genetic modification or implantation of stem cells into patients. Drawing from his training in the Church Lab at Harvard Medical School, Christian sits at the intersection of stem cell biology, translational medicine, and reproductive health. With Gameto's lead product now in Phase III clinical trials, this conversation explores how cell therapies can quietly reshape IVF, why process is often the true product in biotechnology, and what responsible innovation looks like when the stakes include future generations. 00:00 - Gameto’s iPSC product: First FDA phase three clearance in reproductive health 02:08 - Christian Kramme’s background and journey from Harvard to biotech founder 06:26 - How Gameto’s support cell approach differs from other reproductive biotech efforts 10:08 - Current IVF challenges and how support cells enable faster, less drug-dependent treatments 11:52 - Safety measures ensuring support cells do not transfer or integrate into embryos 17:24 - Donor cell line selection, GMP manufacturing, and consistency across lots 21:25 - Clinical trial outcomes so far and operational milestones for scale-up 25:25 - How clinical labs can integrate support cell therapies with existing IVF infrastructure 28:34 - Upcoming trial endpoints, patient recruitment, and next steps 30:52 - Advice for patients navigating infertility and importance of early intervention 34:39 - Ethical considerations in stem cell therapies and responsible…

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