# Polyphron CEO Matthew Osman on his Computation-First Tissue Foundry

Page: https://stenobird.com/podcast/free-radicals-7588534/polyphron-ceo-matthew-osman-on-his-computation-first-tissue-foundry
Text version: https://stenobird.com/podcast/free-radicals-7588534/polyphron-ceo-matthew-osman-on-his-computation-first-tissue-foundry.md
Podcast: [Free Radicals](https://stenobird.com/podcast/free-radicals-7588534)
Published: 2026-01-27T10:00:00+00:00
Episode link: https://podcasters.spotify.com/pod/show/danielshur/episodes/Polyphron-CEO-Matthew-Osman-on-his-Computation-First-Tissue-Foundry-e3e7u70
Audio file: https://anchor.fm/s/107b5162c/podcast/play/114603680/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-0-27%2F416900540-44100-2-40f3b89fdfbaf.mp3
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JSON: https://stenobird.com/v1/public/podcasts/free-radicals-7588534/episodes/polyphron-ceo-matthew-osman-on-his-computation-first-tissue-foundry
Duration seconds: 3183

## Resource

Polyphron is led by co-founder and CEO Matthew Osman, a twice-exited tech entrepreneur turned biotech founder. Matthew is building a computation-first tissue foundry that applies AI and lab automation to semi-autonomously replicate human tissues in a dish. Polyphron aims to create the world’s most efficient tissue foundry for regenerative medicine. Listen to this episode to learn more about the core bet and technological platform at Polyphron, the remarkable progress they’ve made on two programs in heart and brain tissue in just a year, and what’s next for the company.

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## Transcript

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