# Finding genes at scale for age reversal - Shift Bio CEO Daniel Ives

Page: https://stenobird.com/podcast/free-radicals-7588534/finding-genes-at-scale-for-age-reversal-shift-bio-ceo-daniel-ives
Text version: https://stenobird.com/podcast/free-radicals-7588534/finding-genes-at-scale-for-age-reversal-shift-bio-ceo-daniel-ives.md
Podcast: [Free Radicals](https://stenobird.com/podcast/free-radicals-7588534)
Published: 2026-02-03T14:38:01+00:00
Episode link: https://podcasters.spotify.com/pod/show/danielshur/episodes/Finding-genes-at-scale-for-age-reversal---Shift-Bio-CEO-Daniel-Ives-e3ej0vu
Audio file: https://anchor.fm/s/107b5162c/podcast/play/114966974/https%3A%2F%2Fd3ctxlq1ktw2nl.cloudfront.net%2Fstaging%2F2026-1-3%2F417387741-44100-2-e634295edfd4d.mp3
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JSON: https://stenobird.com/v1/public/podcasts/free-radicals-7588534/episodes/finding-genes-at-scale-for-age-reversal-shift-bio-ceo-daniel-ives
Duration seconds: 4673

## Resource

Dr. Daniel Ives is the founder of Shift Bioscience. Shift has built a novel single-cell aging clock that has enabled them to run high-throughput screens to discover genes that regulate aging, with the goal of identifying a therapy to systemically reverse aging. We’ll dive deep into Shift’s latest work on SB000, a germline-expressed gene that rejuvenates cells without inducing pluripotency, and SB101, a pro-aging gene whose inhibition both reverses cellular age and prevents fibrosis, opening a clear path to clinical development. Daniel also shares his philosophy on why reversing aging might be easier than we think, the coming cultural shift when anti-aging drugs become mundane reality, and why he won't rest until we can double human lifespan.

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## Transcript

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