# 155. Dr. Eboni Cornish: Neural Longevity, Brain Inflammation, and the Hidden Root Causes of Mental Health Symptoms

Page: https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/155-dr-eboni-cornish-neural-longevity-brain-inflammation-and-the-hidden-root-causes-of-mental-health-symptoms
Text version: https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213/155-dr-eboni-cornish-neural-longevity-brain-inflammation-and-the-hidden-root-causes-of-mental-health-symptoms.md
Podcast: [Extend Podcast with Darshan Shah, MD](https://stenobird.com/podcast/extend-podcast-with-darshan-shah-md-7064213)
Published: 2026-04-14T08:00:00+00:00
Episode link: https://03add746-5496-41d9-bcc9-511a526491e9.libsyn.com/155-dr-eboni-cornish-neural-longevity-brain-inflammation-and-the-hidden-root-causes-of-mental-health-symptoms
Audio file: https://traffic.libsyn.com/secure/03add746-5496-41d9-bcc9-511a526491e9/Extend_-_Dr._Cornish.mp3?dest-id=4758622
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Duration seconds: 3324

## Resource

Cognitive decline, mood disorders, and persistent neurological symptoms are often treated in isolation, even as underlying drivers like inflammation, infections, and blood flow dysfunction continue to go unaddressed. Emerging research suggests that brain health requires a root cause approach that integrates physiology, environment, and lifestyle over time. In this episode of Extend, we sit down with Dr. Eboni Cornish, Associate Medical Director at Amen Clinics and President Elect of ILADS, to unpack the science of neural longevity and how brain imaging can reveal hidden drivers of mental health symptoms. We break down how SPECT scans uncover patterns of neuroinflammation, why conditions like ADHD and depression may stem from infections, toxins, or hormonal shifts, and how blood flow and cerebellar function play a central role in cognitive performance and emotional regulation. We also explore how factors like sleep apnea, perimenopause, chronic infections, and metabolic dysfunction quietly reshape brain activity and how targeted interventions can restore function over time. Dr. Eboni Cornish is a nationally recognized expert in neuroinflammation and complex chronic illness, integrating advanced biomarker testing with brain imaging to uncover root causes and translate cutting edge science into practical strategies for long term brain and body resilience. What We Discuss: 04:17) Neural longevity and why brain health is missing from longevity conversations. (05:23) SPECT scan imaging and how it reveals brain activity and blood flow. (08:55) Neuroinflammation and root causes behind mental health symptoms. (14:13) The cerebellum as a central regulator of brain function. (17:06) Perimenopause, estrogen decline, and changes in brain perfusion. (23:22) Depression and mood disor…

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