# Ep. 642 Metabolic Health and Brain Aging with Dr. Zaldy Tan | Menopause, Perimenopause, Metabolic Health Page: https://stenobird.com/podcast/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097/ep-642-metabolic-health-and-brain-aging-with-dr-zaldy-tan-menopause-perimenopause-metabolic-health Text version: https://stenobird.com/podcast/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097/ep-642-metabolic-health-and-brain-aging-with-dr-zaldy-tan-menopause-perimenopause-metabolic-health.md Podcast: [Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+](https://stenobird.com/podcast/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097) Published: 2026-09-16T07:00:00+00:00 Episode link: https://traffic.megaphone.fm/CTH3179511140.mp3 Audio file: https://traffic.megaphone.fm/CTH3179511140.mp3 Processing state: not_requested JSON: https://stenobird.com/v1/public/podcasts/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097/episodes/ep-642-metabolic-health-and-brain-aging-with-dr-zaldy-tan-menopause-perimenopause-metabolic-health Duration seconds: 2808 ## Resource Today, I am honored to connect with Dr. Zaldy Tan, a geriatric medicine and memory disorder specialist whose research career has centered on the Framingham Heart Studies Offspring Cohort. Dr. Tan currently directs Cedar Sinai’s memory and healthy aging programs, after previously leading the memory clinic at Beth Israel and Harvard Medical School. His book, Age Proof Your Mind, translates his clinical and research background into a practical framework for people trying to assess and protect their own cognitive trajectory. In our conversation, Dr. Tan explains why middle age is the old age of youth and the youth of old age. We discuss common symptoms of memory issues and those that are reversible. We explore the Framingham Offspring Study and its impact on brain health over time,  looking at the effects of sleep, depression, vitamin deficiencies, alcohol, loneliness, and nutrition, and Dr. Tan shares the three Ds, dementia, delirium, and depression- the red flags he sees in his clinical practice, explains how he helps prepare caregivers for caring for loved ones with neurocognitive memory loss, and discusses late-stage issues, medications, blood-based biomarkers, and the role of genetics in brain health. Stay tuned for a truly fascinating discussion with Dr. Zaldy Tan. IN THIS EPISODE, YOU WILL LEARN: The importance of being sensitive to how your memory changes over time Various factors that could contribute to memory problems The profound effect alcohol has on the brain and neurologic function How social isolation can increase the risk of dementia in future years Dr. Tan discusses the Framingham Offspring Study and the links between metabolic dysregulation and brain MRI markers of brain aging. How the 3 Ds, delirium, dementia, and depression, can overlap The red fl… ## Actions - request_transcript: `POST https://stenobird.com/v1/public/podcasts/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097/episodes/ep-642-metabolic-health-and-brain-aging-with-dr-zaldy-tan-menopause-perimenopause-metabolic-health/transcription-requests` — Idempotently request low-priority transcript generation for this episode. - read_markdown: `GET https://stenobird.com/podcast/everyday-wellness-midlife-hormones-menopause-and-science-for-women-35-72097/ep-642-metabolic-health-and-brain-aging-with-dr-zaldy-tan-menopause-perimenopause-metabolic-health.md` — Read the agent-friendly Markdown representation of this episode resource. A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed. ## Transcript Full transcripts are not published on public pages unless there is a clear rights basis.