# Transcriptional and Epigenetic Regulation of Craniofacial Development (Filippo Rijli)

Page: https://stenobird.com/podcast/epigenetics-podcast-809637/transcriptional-and-epigenetic-regulation-of-craniofacial-development-filippo-rijli
Text version: https://stenobird.com/podcast/epigenetics-podcast-809637/transcriptional-and-epigenetic-regulation-of-craniofacial-development-filippo-rijli.md
Podcast: [Epigenetics Podcast](https://stenobird.com/podcast/epigenetics-podcast-809637)
Published: 2026-05-21T07:01:00+00:00
Episode link: https://activemotif.podbean.com/e/transcriptional-and-epigenetic-regulation-of-craniofacial-development-filippo-rijli/
Audio file: https://mcdn.podbean.com/mf/web/j43cz3ymhrxa47h4/Filippo_final-01-Stefan.mp3
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JSON: https://stenobird.com/v1/public/podcasts/epigenetics-podcast-809637/episodes/transcriptional-and-epigenetic-regulation-of-craniofacial-development-filippo-rijli
Duration seconds: 3093

## Resource

In this episode of the Epigenetics Podcast, we talked with Filippo Rijli from the Friedrich Miescher Institute about his work on transcriptional and epigenetic regulation of craniofacial and neuronal development. Dr. Rijli recalls pivotal moments in his career, including his postdoctoral work where he explored the functions of HoxA2 in craniofacial development. We discuss key findings from his landmark papers, highlighting how individual transcription factors like HoxA2 can dictate the topographic organization of neuronal circuits. His exploration of the whisker-to-barrel cortex circuit in mice unveils how sensory inputs are mapped and processed through precise neuronal connections. This intricate mapping reveals how singular genes can impact the wiring of entire neurological systems. We also reflect on the evolution of scientific communication throughout Filippo’s career, from the reliance on faxes and handwritten requests for paper reprints to today's instant access to research through digital platforms. His early experiences have instilled in him a resourcefulness that continues to inform his approach to research, particularly in environments with limited resources where collaboration becomes essential. Our discussion shifts to his recent research endeavors that delve into transcriptional and epigenetic regulation during neuronal and craniofacial development. Dr. Rijli elaborates on a 2015 study which demonstrated how the ectopic expression of HoxA2 could lead to the creation of artificial whisker maps in the brain, providing insights into how transcription factors guide neuronal behavior and circuit formation. His work on the histone methyltransferase EZH2 reveals its crucial role in the tangential migration of cerebellar neurons and the mechanisms that ensure thes…

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## Transcript

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