# Long-Term Maintenance of Neuronal Identity (Tomohisa Toda)

Page: https://stenobird.com/podcast/epigenetics-podcast-809637/long-term-maintenance-of-neuronal-identity-tomohisa-toda
Text version: https://stenobird.com/podcast/epigenetics-podcast-809637/long-term-maintenance-of-neuronal-identity-tomohisa-toda.md
Podcast: [Epigenetics Podcast](https://stenobird.com/podcast/epigenetics-podcast-809637)
Published: 2026-07-02T07:01:00+00:00
Episode link: https://activemotif.podbean.com/e/long-term-maintenance-of-neuronal-identity-tomohisa-toda/
Audio file: https://mcdn.podbean.com/mf/web/cy9p6zjwcy2rw26a/AMP178_-_Tomohisa_Toda7awyg.mp3
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JSON: https://stenobird.com/v1/public/podcasts/epigenetics-podcast-809637/episodes/long-term-maintenance-of-neuronal-identity-tomohisa-toda
Duration seconds: 2319

## Resource

In this episode of the Epigenetics Podcast, we talked with Tomohisa Toda from the Max-Planck-Zentrum für Physik und Medizin about his work on the long-term maintenance of neuronal identity, with a focus on epigenetic and RNA-based mechanisms in brain stability and aging. Dr. Toda describes how brain circuits are stabilized over time, why critical periods are temporally restricted, and how epigenetic regulation may help maintain established neural identity. This led him to postdoctoral work on neural stem cells and long-term maintenance. We cover his work on nuclear pore and nuclear lamina proteins, including NUP153 and Lamin B1. He explains that NUP153 is enriched in neural stem cells and appears to act as a platform for recruiting factors that help maintain the stem cell epigenome. For Lamin B1, we discuss its decline during aging, how its loss can lead to stem cell exhaustion, reduced adult neurogenesis, and age-related mood dysregulation in the hippocampus. We also discuss LINE-1 RNA, where we learn that reducing LINE-1 promotes neural progenitor differentiation. He explains that this effect is linked to the RNA sequence itself rather than retrotransposition, based on rescue experiments. Finally, we talk about his finding that a subset of postnatally born brain cells contains nuclear RNAs that remain detectable for up to two years. He describes their nuclear enrichment, possible association with heterochromatin, and ongoing work to understand their sequence features, modifications, and biological function. References Bedrosian, T. A., Houtman, J., Eguiguren, J. S., Ghassemzadeh, S., Rund, N., Novaresi, N. M., Hu, L., Parylak, S. L., Denli, A. M., Randolph-Moore, L., Namba, T., Gage, F. H., & Toda, T. (2021). Lamin B1 decline underlies age-related loss of adult h…

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