# Cryo-EM and the Dynamics of TFIID and PRC2 (Eva Nogales)

Page: https://stenobird.com/podcast/epigenetics-podcast-809637/cryo-em-and-the-dynamics-of-tfiid-and-prc2-eva-nogales
Text version: https://stenobird.com/podcast/epigenetics-podcast-809637/cryo-em-and-the-dynamics-of-tfiid-and-prc2-eva-nogales.md
Podcast: [Epigenetics Podcast](https://stenobird.com/podcast/epigenetics-podcast-809637)
Published: 2026-04-09T07:01:00+00:00
Episode link: https://activemotif.podbean.com/e/cryo-em-and-the-dynamics-of-tfiid-and-prc2-eva-nogales/
Audio file: https://mcdn.podbean.com/mf/web/9zsyneuxsjd8icjp/AMP172_-_Eva_Nogalesb5iye.mp3
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JSON: https://stenobird.com/v1/public/podcasts/epigenetics-podcast-809637/episodes/cryo-em-and-the-dynamics-of-tfiid-and-prc2-eva-nogales
Duration seconds: 3107

## Resource

In this episode of the Epigenetics Podcast, we talked with Eva Nogales from UC Berkeley about her work on Cryo-EM and the Dynamics of TFIID and PRC2. We explore the origins of Dr. Nogales's fascination with biology and how her academic journey shifted from physics into the realms of biophysics and structural biology. She shares the profound impact of her training under physicists who instilled a rigorous, quantitative approach to problem-solving, a perspective that continues to influence her work. The importance of visualization emerges as a central theme, showcasing how critical imagery can foster understanding even amidst complex biological structures. A particular focus of our discussion centers on the transcription factor complex TFIID, a significant milestone in Dr. Nogales's career. She recalls the challenging journey to uncovering its structure for the first time, which involved navigating numerous technical hurdles. Dr. Nogales details how their innovative approaches led to insights about the conformational flexibility and functional dynamics of TFIID, especially in relation to its interactions with DNA during transcription initiation. The richness of this narrative reflects both the perseverance required in scientific discovery and the serendipity that often accompanies groundbreaking breakthroughs. Transitioning into the epigenetics realm, Dr. Nogales elucidates the critical role of PRC2 in gene silencing and cellular identity preservation. With a focus on chromatin and nucleosome interactions, we unpack the intricate mechanisms by which PRC2 functions in the context of chromatin remodeling and gene regulation. Dr. Nogales recounts how collaborations and the imaginative contributions of her lab members led to novel research trajectories, particularly the eluc…

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## Transcript

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