# Ep. 176: Embolic Stroke of Undetermined Source: Diagnostic Challenges and Therapeutic Options

Page: https://stenobird.com/podcast/eancast-weekly-neurology-5497158/ep-176-embolic-stroke-of-undetermined-source-diagnostic-challenges-and-therapeutic-options
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Podcast: [eanCast: Weekly Neurology](https://stenobird.com/podcast/eancast-weekly-neurology-5497158)
Published: 2025-11-23T23:15:00+00:00
Episode link: https://eancast.podigee.io/176-neue-episode
Audio file: https://audio.podigee-cdn.net/2219594-m-5c8b93a9dddceebfa0473ed856273d0a.mp3?source=feed
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Duration seconds: 2164

## Resource

Moderator: Theodoros Mavridis (Dublin, Ireland) Guests: Diana Aguiar de Sousa (Lisbon, Portugal), Mira Katan (Basel, Switzerland) Embolic stroke of undetermined source (ESUS) continues to challenge clinicians as its definition and diagnostic approach evolve. In this episode, Theodoros Mavridis is joined by Diana Aguiar de Sousa and Mira Katan. They explore the epidemiological, clinical and mechanistic nuances of ESUS, discuss insights gained from major clinical trials, and examine current therapeutic strategies. The conversation also highlights advances in detecting covert embolic sources, the emerging relevance of atrial myopathy, the role of PFO closure, and the promise of biomarkers in shaping future patient care.

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## Transcript

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