# Depression, I was wrong

Page: https://stenobird.com/podcast/dr-john-campbell-7851784/depression-i-was-wrong
Text version: https://stenobird.com/podcast/dr-john-campbell-7851784/depression-i-was-wrong.md
Podcast: [Dr. John Campbell](https://stenobird.com/podcast/dr-john-campbell-7851784)
Published: 2026-09-14T05:05:00+00:00
Episode link: https://traffic.megaphone.fm/VG3153523228.mp3
Audio file: https://traffic.megaphone.fm/VG3153523228.mp3
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JSON: https://stenobird.com/v1/public/podcasts/dr-john-campbell-7851784/episodes/depression-i-was-wrong
Duration seconds: 1237

## Resource

Depression and serotonin (UK, July 2022) https://www.nature.com/articles/s41380-022-01661-0?utm_medium=affiliate&utm_source=commission_junction&utm_campaign=CONR_PF018_ECOM_GL_PHSS_ALWYS_DEEPLINK&utm_content=textlink&utm_term=PID100094349&CJEVENT=963aad7f0ccb11ed8065b3550a180512 Moncrieff, J., Cooper, R.E., Stockmann, T. et al. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01661-0 The serotonin theory of depression: a systematic umbrella review of the evidence We aimed to synthesise and evaluate evidence, whether depression is associated with lowered serotonin Studies included 17 studies, 12 systematic reviews and meta-analyses, 5 other relevant studies Serotonin metabolite, 5-HIAA levels unchanged https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773935/ Serotonin (neurotransmitter), quickly metabolized Serotonin ----- MAO ------ 5-hydroxy indole acetic acid (5HIAA) (5-hydroxyindoleacetic acid) Plasma 5-HIAA, showed no association with depression Cerebrospinal fluid 5-HIAA, showed no association with depression Plasma serotonin Showed no relationship with depression Several studies of post-menopausal women, revealed lower levels of plasma 5-HT in women with depression, (p more than 0.05) Serotonin receptors 5-HT1A post synaptic receptor In depression (caused by reduced serotonin) expected to show increased activity of 5-HT1A receptors Studies found either no difference in 5-HT1A receptors (between people with depression and controls), or a lower level of these receptors Tryptophan depletion Studies found no effect in healthy volunteers, but weak evidence of an effect in those with a family history of depression Studies of the Serotonin transporter (SERT) gene…

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