# Weird cfDNA Results and ISSUES: May 2026 Data

Page: https://stenobird.com/podcast/dr-chapa-s-obgyn-clinical-pearls-334380/weird-cfdna-results-and-issues-may-2026-data
Text version: https://stenobird.com/podcast/dr-chapa-s-obgyn-clinical-pearls-334380/weird-cfdna-results-and-issues-may-2026-data.md
Podcast: [Dr. Chapa’s OBGYN Clinical Pearls](https://stenobird.com/podcast/dr-chapa-s-obgyn-clinical-pearls-334380)
Published: 2026-05-06T11:00:00+00:00
Episode link: https://podcasters.spotify.com/pod/show/dr-hector-chapa/episodes/Weird-cfDNA-Results-and-ISSUES-May-2026-Data-e3iu4ib
Audio file: https://traffic.megaphone.fm/APO1076624373.mp3
Processing state: processed
JSON: https://stenobird.com/v1/public/podcasts/dr-chapa-s-obgyn-clinical-pearls-334380/episodes/weird-cfdna-results-and-issues-may-2026-data
Duration seconds: 1486

## Resource

Genome-wide noninvasive prenatal testing (GW-NIPT) was introduced in 2015 and became widely available in 2019. Nonetheless, we are still learning more about this important prenatal screening test. In January 2026, the ACOG released a new PA on this, which we will also review in this episode. Our main publication ti review, however, will be the AJOG May 2026’s systematic review and meta-analysis on the finding of “genome-wide” cfDNA discordant results and what this may mean for the pregnancy. Although rare, this may lead (over a third of cases) to some adverse perinatal issues. Listen in for details. 1. ACOG PA Jan 2026: Screening for Fetal Chromosomal Abnormalities 2. AJOG May 2026: https://click.notification.elsevier.com/CL0/https:%2F%2Fwww.ajog.org%2Farticle%2FS0002-9378(25)00865-8%2Ffulltext%3Fdgcid=raven_jbs_etoc_email/1/0100019d9ec37d7b-c586438d-021a-4097-8db3-c158e6f97c9b-000000/Vq6ksekOuvTxcv8OEZZ2uBesCg_hG6qlhqU_BlCnAK4=452

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## Transcript

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