# Incorporating AKT1 and PIK3CA Pathway Testing and Targeted Therapies in the Management of Advanced Endocrine-Resistant Breast Cancer

Page: https://stenobird.com/podcast/decera-clinical-education-oncology-podcast-1302999/incorporating-akt1-and-pik3ca-pathway-testing-and-targeted-therapies-in-the-management-of-advanced-endocrine-resistant-breast-cancer
Text version: https://stenobird.com/podcast/decera-clinical-education-oncology-podcast-1302999/incorporating-akt1-and-pik3ca-pathway-testing-and-targeted-therapies-in-the-management-of-advanced-endocrine-resistant-breast-cancer.md
Podcast: [Decera Clinical Education Oncology Podcast](https://stenobird.com/podcast/decera-clinical-education-oncology-podcast-1302999)
Published: 2026-06-30T18:57:34+00:00
Episode link: https://oncologypodcast.simplecast.com/episodes/incorporating-akt1-and-pik3ca-pathway-testing-and-targeted-therapies-in-the-management-of-advanced-endocrine-resistant-breast-cancer-9JQWI05_
Audio file: https://afp-928689-injected.calisto.simplecastaudio.com/1d8e143b-904e-45be-b6c5-8fba793d9d74/episodes/fe7f0e31-5428-45e0-be14-2351bccbcc23/audio/128/default.mp3?aid=rss_feed&awCollectionId=1d8e143b-904e-45be-b6c5-8fba793d9d74&awEpisodeId=fe7f0e31-5428-45e0-be14-2351bccbcc23&feed=GlfUTtJq
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Duration seconds: 1444

## Resource

Listen to this conversation between Cristina Saura Manich, MD, PhD, and Giampaolo Bianchini, MD, as they discuss practical approaches to PI3K pathway testing, emerging PI3K and AKT-targeted treatment options, and sequencing therapy for patients with metastatic breast cancer following development of endocrine therapy resistance.

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## Transcript

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