# #197 Hypercoagulability Part 2: 5 Pearls Segment Page: https://stenobird.com/podcast/core-im-internal-medicine-podcast-60389/197-hypercoagulability-part-2-5-pearls-segment Text version: https://stenobird.com/podcast/core-im-internal-medicine-podcast-60389/197-hypercoagulability-part-2-5-pearls-segment.md Podcast: [Core IM | Internal Medicine Podcast](https://stenobird.com/podcast/core-im-internal-medicine-podcast-60389) Published: 2026-01-07T09:04:54+00:00 Episode link: https://www.coreimpodcast.com/2026/01/07/hypercoagulability-part-2/ Audio file: https://pscrb.fm/rss/p/audio2.redcircle.com/episodes/fff5139d-429f-4d96-b466-058b6cfad2bc/stream.mp3 Processing state: not_requested JSON: https://stenobird.com/v1/public/podcasts/core-im-internal-medicine-podcast-60389/episodes/197-hypercoagulability-part-2-5-pearls-segment Duration seconds: 2306 ## Resource Gray zones of VTE management! How to approach anticoagulation duration in unprovoked, provoked-irreversible, and provoked-reversible clots? When dose-reduced DOACs make sense for long-term secondary prevention? What truly constitutes DOAC failure? We also devle into how APLAS a critical do-not-miss diagnosis that changes management entirely. 🔹 Sponsor : Pain Management and Opioids Adaptive Learning Free Online Course by NEJM Group: https://cme-info.nejm.org/core-im/ 🔹 Transcript & Shownotes (2:56) - (13:15) | PEARL 1: Managing clots in the “unprovoked”/provoked-irreversible patient (13:21) - (18:10) | PEARL 2: Managing provoked, “reversible” clots (18:14) - (25:14) | PEARL 3: DOAC failure: time to step it up? (25:20) - (37:25) | PEARL 4: APLAS: the exception to everything Tags: CoreIM, Internal Medicine, ClinicalPearls, Medical Education, IMCore, hospitalist, physician assistant, nurse practitioner, medical student, internal medicine, hematology Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy ## Actions - request_transcript: `POST https://stenobird.com/v1/public/podcasts/core-im-internal-medicine-podcast-60389/episodes/197-hypercoagulability-part-2-5-pearls-segment/transcription-requests` — Idempotently request low-priority transcript generation for this episode. - read_markdown: `GET https://stenobird.com/podcast/core-im-internal-medicine-podcast-60389/197-hypercoagulability-part-2-5-pearls-segment.md` — Read the agent-friendly Markdown representation of this episode resource. A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed. ## Transcript Full transcripts are not published on public pages unless there is a clear rights basis.