# Chapter Nine: Regulation of Plasma Osmolality

Page: https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-nine-regulation-of-plasma-osmolality
Text version: https://stenobird.com/podcast/channel-your-enthusiasm-1374325/chapter-nine-regulation-of-plasma-osmolality.md
Podcast: [Channel Your Enthusiasm](https://stenobird.com/podcast/channel-your-enthusiasm-1374325)
Published: 2022-10-31T23:07:46+00:00
Episode link: http://www.rosebook.club/episodes/2022/10/30/chapter-nine
Audio file: https://static1.squarespace.com/static/548bc7f6e4b0a269c594ebc2/t/63605320dd1dd367614d3528/1672426761112/Chapter+9+Channel+Your+Enthusiasm.mp3
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## Resource

References for Chapter 9 One of the few papers that Rose wrote as a single author explores electrolyte free water clearance. This seminal paper explores the issue in greater detail than the book. A New approach to disturbances in the plasma sodium concentration Wondering about the volume of sweat? Josh taught us that the volume of “transepidermal volume loss” is not affected by humidity https://www.jidonline.org/article/S0022-202X(15)48145-X/pdf but is greatly affected by temperature: Skin temperature and transepidermal water loss Regarding normal sweat physiology, there is a nice review (with figures!) titled Physiological mechanisms determining sweat composition which describes all the important cells and channels which make up sweat glands. And an important follow on paper titled Higher Bioelectric Potentials due to Decreased Chloride Absorption in the Sweat Glands of Patients with Cystic Fibrosis describing specifically the sweat characteristics of patients with cystic fibrosis. Melanie was enchanted by work from RA McCance who did early experiments to induce sodium deficiency using very low sodium diets and a homemade sauna-like tent. His musings are fascinating.  Lancet 1936 Experimental human salt deficiency MEDICAL PROBLEMS IN MINERAL METABOLISM Age-related decline in urine concentration may not be universal: Comparative study from the US and two small-scale societies from Jeff Sands (of urea transport fame!) In this initial report, after continually water loading 21 volunteers, the younger group (mean age 31) had a urine osmolality of 52 mOsm/kg compared to in the older group (mean age 84). Influence of age, renal disease, hypertension, diuretics, and calcium on the antidiuretic responses to suboptimal infusions of vasopressin. In a later report older sub…

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