# Turning the Tumor Microenvironment Against Cancer with MGB's Alexander Cryer, Ph.D.

Page: https://stenobird.com/podcast/cell-gene-the-podcast-4048431/turning-the-tumor-microenvironment-against-cancer-with-mgb-s-alexander-cryer-ph-d
Text version: https://stenobird.com/podcast/cell-gene-the-podcast-4048431/turning-the-tumor-microenvironment-against-cancer-with-mgb-s-alexander-cryer-ph-d.md
Podcast: [Cell & Gene: The Podcast](https://stenobird.com/podcast/cell-gene-the-podcast-4048431)
Published: 2025-12-18T11:00:00+00:00
Episode link: https://www.buzzsprout.com/1810482/episodes/18342622-turning-the-tumor-microenvironment-against-cancer-with-mgb-s-alexander-cryer-ph-d.mp3
Audio file: https://www.buzzsprout.com/1810482/episodes/18342622-turning-the-tumor-microenvironment-against-cancer-with-mgb-s-alexander-cryer-ph-d.mp3
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Duration seconds: 985

## Resource

We love to hear from our listeners. Send us a message. In Episode 118, Host Erin Harris talks to Alexander Cryer, Ph.D., Instructor in Medicine at Mass General Brigham, about a proof of concept strategy that reprograms tumor cells with mRNA lipid nanoparticles to overactivate the cGAS-STING pathway, forcing cancer cells to produce and export large amounts of the innate immune agonist cGAMP to stimulate surrounding immune cells and drive anti-tumor immunity. Dr. Cryer explains the basic biolog...

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## Transcript

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