# From Partnered ASO Therapies To A Wholly-Owned Pipeline With Ionis's Brett Monia, Ph.D.

Page: https://stenobird.com/podcast/business-of-biotech-123501/from-partnered-aso-therapies-to-a-wholly-owned-pipeline-with-ionis-s-brett-monia-ph-d
Text version: https://stenobird.com/podcast/business-of-biotech-123501/from-partnered-aso-therapies-to-a-wholly-owned-pipeline-with-ionis-s-brett-monia-ph-d.md
Podcast: [Business Of Biotech](https://stenobird.com/podcast/business-of-biotech-123501)
Published: 2026-05-04T10:00:00+00:00
Episode link: https://www.buzzsprout.com/1011661/episodes/19096332-from-partnered-aso-therapies-to-a-wholly-owned-pipeline-with-ionis-s-brett-monia-ph-d.mp3
Audio file: https://www.buzzsprout.com/1011661/episodes/19096332-from-partnered-aso-therapies-to-a-wholly-owned-pipeline-with-ionis-s-brett-monia-ph-d.mp3
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Duration seconds: 3356

## Resource

We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, Brett Monia, Ph.D., CEO at Ionis Pharmaceuticals, talks about how antisense oligonucleotides (ASO) graduated from a late-1980s lab concept to real RNA-targeting medicines, and why Ionis stuck with a difficult modality despite multiple setbacks. Brett describes the company's shift from a partner-first model to building a wholly-owned pipeline, commercial function, and an expanded manufact...

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