# HR-Positive Metastatic Breast Cancer — Year in Review Series on Relevant New Datasets and Advances in the PI3K/AKT/mTOR Pathway

Page: https://stenobird.com/podcast/breast-cancer-update-757579/hr-positive-metastatic-breast-cancer-year-in-review-series-on-relevant-new-datasets-and-advances-in-the-pi3k-akt-mtor-pathway
Text version: https://stenobird.com/podcast/breast-cancer-update-757579/hr-positive-metastatic-breast-cancer-year-in-review-series-on-relevant-new-datasets-and-advances-in-the-pi3k-akt-mtor-pathway.md
Podcast: [Breast Cancer Update](https://stenobird.com/podcast/breast-cancer-update-757579)
Published: 2026-08-24T18:00:00+00:00
Episode link: https://breast-oncology.captivate.fm/episode/6110-yir2025-pi3k-akt-mtor-bc
Audio file: https://dts.podtrac.com/redirect.mp3/episodes.captivate.fm/episode/2573d8f1-50f7-4a7d-a4f5-499c4a29f9bd.mp3
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Duration seconds: 3534

## Resource

Featuring perspectives from Dr Virginia Kaklamani and Dr Hope S Rugo, including the following topics: Introduction: San Antonio Memories (0:00) PI3K/AKT/PTEN Alterations and Therapies (7:18) Capivasertib (20:22) Gedatolisib (34:08) Inavolisib (47:07) New Agents and Ongoing Trials (52:34) CME information and select publications

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## Transcript

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