# For Oncology Nurses: Targeting the PI3K/AKT/mTOR Pathway in HR-Positive Metastatic Breast Cancer — Proceedings from the 2026 Annual ONS Congress

Page: https://stenobird.com/podcast/breast-cancer-update-757579/for-oncology-nurses-targeting-the-pi3k-akt-mtor-pathway-in-hr-positive-metastatic-breast-cancer-proceedings-from-the-2026-annual-ons-congress
Text version: https://stenobird.com/podcast/breast-cancer-update-757579/for-oncology-nurses-targeting-the-pi3k-akt-mtor-pathway-in-hr-positive-metastatic-breast-cancer-proceedings-from-the-2026-annual-ons-congress.md
Podcast: [Breast Cancer Update](https://stenobird.com/podcast/breast-cancer-update-757579)
Published: 2026-08-10T13:00:00+00:00
Episode link: https://breast-oncology.captivate.fm/episode/6020-ons2026-pi3k-akt-mtor-mbc
Audio file: https://dts.podtrac.com/redirect.mp3/episodes.captivate.fm/episode/4cc3eced-fbc6-4382-b7d7-e4f28f8d02b2.mp3
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Duration seconds: 5396

## Resource

Featuring perspectives from Dr Reva Basho, Ms Kelly Fischer, Ms Melissa Rikal and Dr Seth Wander, moderated by Dr Wander, including the following topics: Introduction (00:00) Identification of Appropriate Candidates for Agents Targeting the PI3K/AKT/mTOR Pathway (3:45) Role of Inavolisib in HR-Positive Metastatic Breast Cancer (mBC) (13:00) Strategies to Prevent and Manage Hyperglycemia (27:02) Clinical Utility of Capivasertib for HR-Positive mBC (38:09) Mitigation and Management of Gastrointestinal Adverse Events (51:05) Management of Dermatologic Adverse Events (59:58) Potential Role of Gedatolisib in the Management of HR-Positive mBC (1:08:42) Monitoring and Management of Cytopenias (1:21:23) CME information and select publications

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