# Pathophysiology of ANKRD26-related thrombocytopenia and B-ALL recurrence after blinatumomab

Page: https://stenobird.com/podcast/blood-podcast-664776/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab
Text version: https://stenobird.com/podcast/blood-podcast-664776/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-04-23T16:00:00+00:00
Episode link: https://share.transistor.fm/s/f867a52e
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/f867a52e/d7907794.mp3
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JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/pathophysiology-of-ankrd26-related-thrombocytopenia-and-b-all-recurrence-after-blinatumomab
Duration seconds: 1164

## Resource

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Shengwen Calvin Li and Hrishi Krishna Srinagesh on their latest articles published in Blood . Dr. Li discusses " Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 ". The study identifies reproducible abnormalities in progenitor expansion and increased apoptosis of polyploid megakaryocytes, and they propose a novel mechanism in which centrosomal over-expression of ANKRD26 drives polyploid megakaryocyte apoptosis through JUNB-mediated induction of p21 transcription. Dr. Srinagesh discusses " Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL " in which data collected by the Real-World Outcomes Collaborative of CAR-T in Adult ALL consortium showed that prior nonresponse to blinatumomab was associated with inferior survival after brexucabtagene in comparison to blinatumomab-naïve patients. Early CAR-T responses were uniformly high regardless of prior exposure or response. This highlights that resistance to blinatumomab may identify patients at higher risk of post–CAR T relapse despite excellent initial responses.

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