# Orca-T for GVHD–free survival and Understanding VEXAS anemia

Page: https://stenobird.com/podcast/blood-podcast-664776/orca-t-for-gvhd-free-survival-and-understanding-vexas-anemia
Text version: https://stenobird.com/podcast/blood-podcast-664776/orca-t-for-gvhd-free-survival-and-understanding-vexas-anemia.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-06-25T16:00:00+00:00
Episode link: https://share.transistor.fm/s/ae7ba399
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/ae7ba399/9808c6b1.mp3
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JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/orca-t-for-gvhd-free-survival-and-understanding-vexas-anemia
Duration seconds: 1384

## Resource

In this week's episode, Blood editor Dr. Laurie Sehn interviews Drs. Everett Meyer and Olivier Hermine on their latest articles published in volume 147 issue 11 of Blood . Dr. Everett Meyer discusses " Orca-T vs allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial " which demonstrated that Orca-T showed superior chronic GVHD–free survival compared to the control arm (78.0% vs 38.4%, P < .001) and lower nonrelapse mortality (3.4% vs 13.2%, P = .03). Dr. Olivier Hermine shares insights from " VEXAS anemia is a mosaic erythroblastopenia " which proposes that VEXAS syndrome–associated anemia should be considered as a mosaic erythroblastopenia, in which the severity of anemia is influenced by the quality and quantity of the UBA1 –wild-type compartment.

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## Transcript

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