# New Approaches: Marstacimab Therapy and HLH Biomarkers

Page: https://stenobird.com/podcast/blood-podcast-664776/new-approaches-marstacimab-therapy-and-hlh-biomarkers
Text version: https://stenobird.com/podcast/blood-podcast-664776/new-approaches-marstacimab-therapy-and-hlh-biomarkers.md
Podcast: [Blood Podcast](https://stenobird.com/podcast/blood-podcast-664776)
Published: 2026-05-28T16:00:00+00:00
Episode link: https://share.transistor.fm/s/18f11dc5
Audio file: https://prfx.byspotify.com/e/media.transistor.fm/18f11dc5/085b0d58.mp3
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JSON: https://stenobird.com/v1/public/podcasts/blood-podcast-664776/episodes/new-approaches-marstacimab-therapy-and-hlh-biomarkers
Duration seconds: 1070

## Resource

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood . Dr. Mahlangu discusses study details and next steps from " Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial " which shows that bleeding was reduced by 93% with subcutaneous marstacimab. Dr. Rocco shares the development behind " CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis ", and the insights gained from measuring a new surrogate marker of IFN-γ activity predicting severity and mortality.

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## Transcript

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