# Episode 58: CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN) with Dr. Piers Blombery

Page: https://stenobird.com/podcast/blood-cancer-talks-5570002/episode-58-car-transgenic-t-cell-lymphoproliferative-neoplasms-cttln-with-dr-piers-blombery
Text version: https://stenobird.com/podcast/blood-cancer-talks-5570002/episode-58-car-transgenic-t-cell-lymphoproliferative-neoplasms-cttln-with-dr-piers-blombery.md
Podcast: [Blood Cancer Talks](https://stenobird.com/podcast/blood-cancer-talks-5570002)
Published: 2025-03-26T10:22:25+00:00
Episode link: https://share.transistor.fm/s/9da2f779
Audio file: https://media.transistor.fm/9da2f779/ac668be8.mp3
Processing state: not_requested
JSON: https://stenobird.com/v1/public/podcasts/blood-cancer-talks-5570002/episodes/episode-58-car-transgenic-t-cell-lymphoproliferative-neoplasms-cttln-with-dr-piers-blombery
Duration seconds: 3024

## Resource

In this episode, we explore the emerging entity of CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN), a rare but important complication of CAR T-cell therapy. Dr. Piers Blombery from Peter MacCallum Cancer Center joins us to dissect two cases from the CARTITUDE-4 trial where patients developed T-cell lymphomas expressing the chimeric antigen receptor following cilta-cel treatment for multiple myeloma. As a bonus, we also briefly discussed Dr. Blombery’s paper on menin inhibitors in UBTF tandem duplicated AML. Here are the papers we discussed: 1. CTTLN cases from CARTITUDE-4: https://pubmed.ncbi.nlm.nih.gov/39938094/ 2. CTTLN case from MSKCC with insertional mutagenesis: https://pubmed.ncbi.nlm.nih.gov/39908432/ 3. Other CTTLN cases in myeloma: https://pubmed.ncbi.nlm.nih.gov/38865661/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8417502/ 4. Response and resistance to menin inhibitors in UBTF tandem duplication AML: https://pubmed.ncbi.nlm.nih.gov/38924737/

## Actions

- request_transcript: `POST https://stenobird.com/v1/public/podcasts/blood-cancer-talks-5570002/episodes/episode-58-car-transgenic-t-cell-lymphoproliferative-neoplasms-cttln-with-dr-piers-blombery/transcription-requests` — Idempotently request low-priority transcript generation for this episode.
- read_markdown: `GET https://stenobird.com/podcast/blood-cancer-talks-5570002/episode-58-car-transgenic-t-cell-lymphoproliferative-neoplasms-cttln-with-dr-piers-blombery.md` — Read the agent-friendly Markdown representation of this episode resource.

A page view does not enqueue transcription. Agents should invoke `request_transcript` explicitly when they need this episode processed.

## Transcript

Full transcripts are not published on public pages unless there is a clear rights basis.