# Breaking "Wine O'Clock": Psilocybin, Saffron, Microdosing and Upgrading Women's Mental Health with Keegan Downer

Page: https://stenobird.com/podcast/biohacking-with-brittany-783841/breaking-wine-o-clock-psilocybin-saffron-microdosing-and-upgrading-women-s-mental-health-with-keegan-downer
Text version: https://stenobird.com/podcast/biohacking-with-brittany-783841/breaking-wine-o-clock-psilocybin-saffron-microdosing-and-upgrading-women-s-mental-health-with-keegan-downer.md
Podcast: [Biohacking with Brittany](https://stenobird.com/podcast/biohacking-with-brittany-783841)
Published: 2026-02-19T09:10:00+00:00
Episode link: https://biohackingbrittany.com/blogs/podcast/429
Audio file: https://traffic.libsyn.com/secure/biohackingwithbrittany/Ep_429_FINAL_AUDIO.mp3?dest-id=1326614
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JSON: https://stenobird.com/v1/public/podcasts/biohacking-with-brittany-783841/episodes/breaking-wine-o-clock-psilocybin-saffron-microdosing-and-upgrading-women-s-mental-health-with-keegan-downer
Duration seconds: 3548

## Resource

Keegan Downer (Founder of mindfulMEDS ) shares how he went from alcohol addiction and a near-suicidal breaking point, to recovery and to building one of Canada's most recognized microdosing education brands, and why psilocybin doesn't have to be "woo." We also get super practical: What microdosing actually feels like day-to-day, why it can hit women differently (especially moms), how psilocybin compares to SSRIs (Selective Serotonin Reuptake Inhibitor) when it comes to emotional processing, and why "wine o'clock" culture is quietly keeping so many women stuck in a stress-and-numb cycle. Want protocols built specifically for women, live coaching, and real talk about peptides and longevity? That's what The LongHer Life is for. Private. Uncensored. Ongoing. https://biohackingbrittany.com/pages/longherlife WE TALK ABOUT: 05:40 - Keegan's life collapse that led to addiction and the "rooftop moment" 07:45 - Rebuilding purpose after rehab and the anxiety attack that changed everything 09:10 - Why microdosing went from "nobody's talking about this" to mainstream fast 12:35 - The day-13 breakthrough and the microdosing study that launched his mission 19:30 - Why psilocybin and SSRIs create totally different emotional outcomes 23:20 - When microdosing feels "too strong" and how dose + setting change everything 28:40 - The dose reality check: "microdose" vs "creative dose" and why sensitivity matters 38:20 - Why women (especially moms) are the fastest-growing microdosing segment 41:05 - "Wine o'clock" culture, addiction masking, and the uncomfortable truth 44:00 - Brainbow: The saffron extract approach for mood, sleep, and nervous system support 57:10 - Where to learn more, the free microdosing guide, and weekly consults RESOURCES: Want protocols built specifically for women, liv…

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## Transcript

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