# EP231: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 2 - Dayan Goodenowe, PhD

Page: https://stenobird.com/podcast/betterhealthguy-podcast-222585/ep231-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-2-dayan-goodenowe-phd
Text version: https://stenobird.com/podcast/betterhealthguy-podcast-222585/ep231-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-2-dayan-goodenowe-phd.md
Podcast: [BetterHealthGuy Podcast](https://stenobird.com/podcast/betterhealthguy-podcast-222585)
Published: 2026-04-22T12:23:00+00:00
Episode link: https://betterhealthguy.com/ep231
Audio file: https://traffic.libsyn.com/secure/betterhealthguy/231.mp3?dest-id=488186
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JSON: https://stenobird.com/v1/public/podcasts/betterhealthguy-podcast-222585/episodes/ep231-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-2-dayan-goodenowe-phd
Duration seconds: 6983

## Resource

🎧 Episode Summary This episode continues the conversation with Dayan Goodenowe, PhD, exploring the shared biochemical patterns underlying conditions such as autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's, Parkinson's, MS, and ALS. The discussion examines how environmental stressors, metabolic and lipid dysfunction, and oxidative stress contribute to loss of resilience and disease progression. Dr. Goodenowe also highlights the role of biomarkers, advanced testing, and targeted support—including plasmalogens and methylation—in identifying prodromes and restoring function across complex chronic conditions. 🧭 In This Episode - Similarities and differences across autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, and ALS - Prodromes as loss of resilience and early deviation from health - Aging as entropy and biochemical insufficiency rather than a programmed disease process - Metabolic sufficiency, mitochondrial function, and lipid membrane integrity as core systems in adaptation - Oxidative stress, inflammatory markers, and reserve capacity in chronic illness - ProdromeScan and BioMetrix Bioscan differences in scope, interpretation, and monitoring - Standard biomarkers associated with compromised peroxisomal function and low plasmalogens - NAD, niacin, spermidine, and urolithin A in relation to mitochondrial and cellular function - Alzheimer's disease mechanisms involving DHA plasmalogen depletion, amyloid formation, acetylcholine dysfunction, and methyltransferase stress - Phosphatidylcholine and dietary choline as support for acetylcholine production and membrane health - Brain volumetrics, cortical thickness, white matter density, and advanced MRI measures of structural recovery - Traumatic brain…

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