# EP230: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 1 - Dayan Goodenowe, PhD

Page: https://stenobird.com/podcast/betterhealthguy-podcast-222585/ep230-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-1-dayan-goodenowe-phd
Text version: https://stenobird.com/podcast/betterhealthguy-podcast-222585/ep230-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-1-dayan-goodenowe-phd.md
Podcast: [BetterHealthGuy Podcast](https://stenobird.com/podcast/betterhealthguy-podcast-222585)
Published: 2026-04-06T18:46:00+00:00
Episode link: https://betterhealthguy.com/ep230
Audio file: https://traffic.libsyn.com/secure/betterhealthguy/230.mp3?dest-id=488186
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JSON: https://stenobird.com/v1/public/podcasts/betterhealthguy-podcast-222585/episodes/ep230-lipid-biology-plasmalogens-and-neurodegenerative-prodromes-part-1-dayan-goodenowe-phd
Duration seconds: 7086

## Resource

🎧 Episode Summary This episode explores the foundational role of lipid biology and plasmalogens in cellular health, inflammation, and neurodegenerative patterns. Dayan Goodenowe, PhD discusses how membrane composition, oxidative stress, and environmental factors influence cellular function, along with the potential impact of plasmalogen precursor therapies on cognition, resilience, and overall system regulation. 🧭 In This Episode - Lipid membrane composition differences across cell types and organelles - Phospholipid bilayer structure and hydrophilic–hydrophobic organization - Functional role of membrane lipids in cellular compartmentalization - Variability of lipid composition within different regions of a single cell - Impact of oxidative stress on membrane lipid composition and function - Mechanism of phospholipid peroxidation and phospholipase-mediated removal - Relationship between membrane rigidity and cellular signaling capacity - Mitochondrial dysfunction and its role in the Cell Danger Response - Nutrient and cofactor requirements for mitochondrial energy production - Interaction between membrane lipid integrity and mitochondrial performance - Immune activation triggered by peroxidized membrane lipids - Functional differences between omega-9 and omega-3 plasmalogen precursors - Role of plasmalogens in synaptic transmission and neurotransmitter release 👤 About the Guest Dayan Goodenowe, PhD, is a neuroscientist, biochemist, inventor, and clinical research expert. In 1999, he invented and patented ion cyclotron resonance mass spectrometry technology, enabling comprehensive monitoring of human biochemistry for the first time. Using this technology, Dr. Goodenowe analyzed blood samples from tens of thousands of individuals of all ages and races, from multiple coun…

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