# SEVOFLURANE, ISOFLURANE, DESFLURANE: WHICH ONE AND WHEN?

Page: https://stenobird.com/podcast/atomic-anesthesia-6877117/sevoflurane-isoflurane-desflurane-which-one-and-when
Text version: https://stenobird.com/podcast/atomic-anesthesia-6877117/sevoflurane-isoflurane-desflurane-which-one-and-when.md
Podcast: [Atomic Anesthesia](https://stenobird.com/podcast/atomic-anesthesia-6877117)
Published: 2026-06-09T13:38:00+00:00
Episode link: https://atomic-anesthesia.captivate.fm
Audio file: https://episodes.captivate.fm/episode/c0d054c1-0bbc-420b-b980-558bae58f0c2.mp3
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JSON: https://stenobird.com/v1/public/podcasts/atomic-anesthesia-6877117/episodes/sevoflurane-isoflurane-desflurane-which-one-and-when
Duration seconds: 1728

## Resource

Welcome to the Atomic Anesthesia podcast hosted by CRNA professor Dr. Rhea Temmermand and Co-Founder Sachi Lord. On this show, you'll hear clear, clinically grounded discussions designed for nurse anesthesia residents and CRNAs who want to feel more confident in complex pharmacology, physiology, and real-world anesthesia decision-making. Want more content like this? Become a member of our learning platform: http://atomicanesthesia.com In this episode: Why desflurane needs its own specialized Tec 6 vaporizer (and what its 22.8°C boiling point means for safe delivery) The four inhalational agents you need to know cold — sevoflurane, isoflurane, desflurane, nitrous oxide — with MAC values, blood:gas coefficients, and clinical trade-offs How coronary steal actually works with isoflurane, and when it matters at the bedside The second gas effect explained at the alveolar level: concentrating effect + augmented inflow Compound A, carbon monoxide, methionine synthase inhibition — the metabolic pitfalls each agent brings to a case Tailoring agent choice for pediatric, geriatric, pregnant, neuro, and cardiac patients 💜 FREE DOWNLOADS: Grab your copy of customized study plans & worksheets. GPCR Cheat Sheet — G-protein coupled receptors decoded for anesthesia SEE/NCE Study Plan — a structured, week-by-week plan to pass your boards Non-Opioid Pharmacology Cheat Sheet — every non-opioid analgesic you need to know, one page 💜 CONNECT: 📥 Email questions, comments or topic suggestions to Dr. Temmermand at hello@atomicanesthesia.com, follow us on social media, and sign up for our newsletter. 💜 PARTNERS: The Incomologists® https://theincomologists.com/ You work hard caring for others—let us take care of you. Whether you're a W-2 employee or transitioning to a 1099 role, we understand…

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## Transcript

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